多拉菌素浇泼剂在犬体内的药代动力学

›› 2012, Vol. 39 ›› Issue (6): 156-160.

多拉菌素浇泼剂在犬体内的药代动力学

李海琴¹, 陈云², 朱华君¹, 颜诚¹, 元晓琪¹, 贾雪霞¹, 唐兆新¹

1. 华南农业大学兽医学院,广东广州 510642;
2. 佛山科技学院技术学院生命科学学院,广东佛山 528231

修回日期:2011-11-09 出版日期:2012-06-20 发布日期:2012-07-02
通讯作者: 唐兆新(1962－),男,安徽人,博士生导师,教授。E-mail: tangzhaoxin@hotmail.com E-mail:tangzhaoxin@hotmail.com
作者简介:李海琴(1986－),女,江西人,硕士,主要从事宠物兽药方面的研究。

Pharmacokinetics of the Pour-on Preparation of Doramectin in Dogs

LI Hai-qin¹, CHEN Yun², ZHU Hua-jun¹, YAN Cheng¹, YUAN Xiao-qi¹, JIA Xue-xia¹, TANG Zhao-xin¹

1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China;
2. College of Life Sciences, Foshan University, Foshan 528231, China

Revised:2011-11-09 Online:2012-06-20 Published:2012-07-02

摘要/Abstract

摘要： 本试验对多拉菌素浇泼剂在犬血浆中的药代动力学进行了研究。犬背部皮肤一次浇注多拉菌素浇泼剂(0.1 mg/kg体重),给药后,不同时间点从犬前肢静脉采血。以高效液相色谱法对血浆中药物浓度进行测定,血浆药物浓度—时间数据用WinNonlin 5.2.1的非房室模型药动软件处理。给药后的主要药物动力学参数为:t1/2β为(2.14±0.56)d,T_max为(1.00±0.00) d,C_max为(24.38±4.82) ng/mL,AUC为(89.79±16.90)ng/(d·mL)。提示多拉菌素浇泼剂在犬体内血药浓度维持的时间较长,消除缓慢。

关键词: 药物代谢动力学; 多拉菌素; 浇泼剂

Abstract: Pharmacokinetics studies of pour-on of doramectin in dog blood plasma. Drow blood from the jugular vein of the dogs in different time after used the pour-on of doramectin one time on the skin of back with the concentration 0.1 mg/kg·bw. We used the method of the HPLC to detect the concentration of the doramectin in the blood plasma. The blood plasma doramectin concentration and time data was processed by the non compartment analysis of the WinNonlin5.2.1 software. The main pharmacokinetic parameters were the maximum concentration (C_max) of the doramectin in the blood plasma is (24.38±4.82) ng/mL, and the time is (1.00±0.00) d (T_max)after we used the doramectin pour-on. The elimination half life (t1/2β) is (2.14±0.56) d. Area under curve (AUC) is (89.79±16.90) ng/(d·mL). The results showed that doramectin has a long persistence in the plasma concentrations and eliminated slowly in dogs.

Key words: pharmacokinetics; doramectin; pour-on preparation

中图分类号:

S859.7

李海琴, 陈云, 朱华君, 颜诚, 元晓琪, 贾雪霞, 唐兆新. 多拉菌素浇泼剂在犬体内的药代动力学[J]. , 2012, 39(6): 156-160.

LI Hai-qin, CHEN Yun, ZHU Hua-jun, YAN Cheng, YUAN Xiao-qi, JIA Xue-xia, TANG Zhao-xin. Pharmacokinetics of the Pour-on Preparation of Doramectin in Dogs[J]. , 2012, 39(6): 156-160.

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