氧化乐果对雄性小鼠睾丸琥珀酸脱氢酶和精液质量的影响

›› 2011, Vol. 38 ›› Issue (7): 148-150.

氧化乐果对雄性小鼠睾丸琥珀酸脱氢酶和精液质量的影响

徐光翠¹, 高启禹², 韩光亮¹, 王二曼¹

1. 河南新乡医学院公共卫生学系卫生毒理学教研室,河南新乡 453003;2. 河南新乡医学院生命科学技术系医用生物学教研室,河南新乡 453003

收稿日期:2010-12-27 修回日期:1900-01-01 出版日期:2011-07-20 发布日期:2011-07-20

Effect of Omethoate on the Testis Succinic Dehydrogenase (SDH) and the Quality of Sperm in Male Mice

XU Guang-cui¹, GAO Qi-yu², HAN Guang-liang¹, WANG Er-man¹

1. Toxicology Teaching and Research Section of the Department of Public Health, Xinxiang Medical University, Xinxiang 453003,China;2. Applied Biology Section of the Department of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003,China

Received:2010-12-27 Revised:1900-01-01 Online:2011-07-20 Published:2011-07-20

摘要/Abstract

摘要： 试验旨在研究有机磷农药氧化乐果对雄性小鼠睾丸琥珀酸脱氢酶(SDH)和精液质量的影响作用。将40只健康昆明雄性小鼠随机分为4组,即低、中、高3个染毒组和对照组,其中染毒组分别灌胃1.0、2.0、4.0 mg/kg氧化乐果,对照组灌胃生理盐水,采用等容量灌胃法(0.2 mL/10 g体重),连续灌胃14 d。随着氧化乐果染毒剂量的逐渐增加,小鼠睾丸琥珀酸脱氢酶(SDH)活力、精子密度、存活率均明显降低,与对照组相比差异显著(P＜0.05);小鼠体重、睾丸重、附睾及其脏器系数与对照组相比差异均不显著(P＞0.05)。氧化乐果对小鼠精子密度和精子存活率有一定的损伤作用,对睾丸琥珀酸脱氢酶有明显的抑制作用。

关键词: 雄性生殖系统; 氧化乐果; 琥珀酸脱氢酶; 精液质量

Abstract: To explore the adverse effect of omethoate on activity of the testicle succinic dehydrogenase (SDH) and the quality of sperm in mice. 40 male Kunming mice were distributed randomly into 4 groups including the control group, low dose omethote (1.0 mg/kg), middle dose omethote(2.0 mg/kg) and high dose omethote (4.0 mg/kg). The experiment groups were primed through mouth with omethoate and the control group with 0.9% saline for 14 days. As the omethoate doses was increased, the activity of succinic dehydrogenase (SDH), the number of sperm and the rate of living sperm were decreased significantly compared with the control group(P＜0.05).The testis weight and epididymal viscera of mice were not statistically significant compared with the control group (P＞0.05). The omethoate was toxic to the reproductive system in the mice and could damage the density of sperm and the rate of living sperm, inhibit the activity of SDH.

Key words: reproductive toxicity; omethoate; SDH; the quality of sperm

中图分类号:

R339.2⁺1

徐光翠;高启禹;韩光亮;王二曼. 氧化乐果对雄性小鼠睾丸琥珀酸脱氢酶和精液质量的影响[J]. , 2011, 38(7): 148-150.

XU Guang-cui;GAO Qi-yu;HAN Guang-liang;WANG Er-man. Effect of Omethoate on the Testis Succinic Dehydrogenase (SDH) and the Quality of Sperm in Male Mice[J]. , 2011, 38(7): 148-150.

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