关键词: 纤维样淀粉物质; 固态核磁共振; 氢氘交换

Abstract: Interest in understanding the structural basis of amyloid formation has been strongly motivated by their association with a number of diseases, such as Alzheimer's (AD), Parkinson's, and prion diseases. However, the structure of amyloid is still not very clear. Here, we described some of the most commonly used techniques, such as hydrogen-deuterium exchange, cryoelectron microscopy and solid-state nuclear magnetic resonance, employed in amyloid structure characterization. These techniques enabled high-resolution insights into molecular organization of amyloid.

Key words: amyloid; solid-state NMR; hydrogen-deuterium exchange