熊果酸介导HIF-1α缓解木质化鸡胸肉发生的潜在作用机制研究

doi:10.16431/j.cnki.1671-7236.2024.04.016

摘要/Abstract

摘要： 木质化鸡胸肉在快大型白羽肉鸡的胸肌组织中病变率高达20%,严重降低消费者的购买欲,也不利于后期加工,造成的经济损失相对较高。缺氧是导致木质化鸡胸肉发生的重要原因,缺氧诱导因子1α(HIF-1α)是机体缺氧状态下调节细胞功能的关键因子,缺氧会造成HIF-1α过表达,导致机体氧化应激、糖代谢紊乱和炎症反应的发生,进而导致快大型白羽肉鸡罹患木质化鸡胸肉。熊果酸具有抗氧化、抗炎和调节糖代谢等功效,并可通过腺苷酸激活蛋白激酶(AMPK)、磷脂酰肌醇3激酶/蛋白激酶B (PI3K/Akt)等信号通路调节HIF-1α在机体中的表达。作者综述了缺氧所导致的木质化鸡胸肉的发病机理以及熊果酸调控HIF-1α对氧化应激、糖代谢和炎症反应的影响,进一步分析了熊果酸通过AMPK、PI3K/Akt等信号通路调控HIF-1α缓解木质化鸡胸肉发生的潜在作用机制。

关键词: 木质化鸡胸肉; 熊果酸; 缺氧诱导因子1α(HIF-1α)

Abstract: The lesion rate of woody breast is as high as 20% in fast-growing White feather broiler,it seriously reduces consumers’ desire to buy,and is not conducive to post-processing,resulting in relatively high economic losses.Hypoxia is an important cause of woody breast,and hypoxia inducible factor 1α (HIF-1α) is a key factor in regulating cell function under hypoxia.Ursolic acid has the effects of anti-oxidation,anti-inflammatory and regulating glucose metabolism,and can regulate the expression of HIF-1α through adenylate-activated protein kinase (AMPK) and phosphatidylinositol kinase-3 kinase-protein kinase B (PI3K/Akt) signaling pathways.Therefore,the author reviews the pathogenesis of woody breast caused by hypoxia and how HIF-1α mediated glucose metabolism,oxidative stress and inflammatory responses are regulated by ursolic acid,and further analyzes the potential mechanism of ursolic acid regulating HIF-1α to alleviate the occurrence of woody breast through AMPK,PI3K/Akt and other signaling pathways.

Key words: woody breast; ursolic acid; hypoxia inducible factor 1α (HIF-1α)

中图分类号:

S831.7

张喜闻, 李响, 尹月, 赵玉蓉. 熊果酸介导HIF-1α缓解木质化鸡胸肉发生的潜在作用机制研究[J]. 中国畜牧兽医, 2024, 51(4): 1480-1489.

ZHANG Xiwen, LI Xiang, YIN Yue, ZHAO Yurong. Study on Ursolic Acid Mediated Hypoxia Inducible Factor 1α Potential Mechanisms for Alleviating the Occurrence of Woody Breast[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(4): 1480-1489.

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