口蹄疫病毒前导蛋白酶抑制宿主先天性免疫应答的机制

doi:10.16431/j.cnki.1671-7236.2015.04.039

Abstract

Abstract: Foot-and-mouth disease (FMD) is an acute, febrile, highly contagious animal disease caused by foot-and-mouth disease virus (FMDV). FMDV has a variety of mechanisms resisting host innate immune response, leader protease (L^pro) has played a key role in the process. L^pro can cut off the host cell cap-dependent translation, inhibiting the synthesis of interferon. L^pro through destroying the integrity of NF-κB or reducing the expression of IRF3/7, inhibits the production of interferons mRNA. Besides, L^pro can take part in the deubiquitination of reninoic-acid-inducible gene Ⅰ (RIG-Ⅰ), TANK binding kinase 1 (TBK1), TNF receptor-associate factor 3 (TRAF3) and TRAF6, thus affecting the activation of type Ⅰ interferon signaling pathway.

Key words: FMDV; leader protease; typeⅠinterferon; innate immune response

CLC Number:

S852.65

LI Xia-ying, XU Wen-tao, WANG Qi-huai. Mechanism of Foot-and-mouth Disease Virus Leader Protease to Inhibit Host Innate Immune Response[J]. , 2015, 42(4): 1028-1031.

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Mechanism of Foot-and-mouth Disease Virus Leader Protease to Inhibit Host Innate Immune Response

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