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Essential Amino Acid Upregulates L-type Amino Acid Transporter 1 Expression in Mammary Acinus

LIN Ye, HOU Xiao-ming, TIAN Lei, QI Bang-ruo, LI Qing-zhang   

  1. (Key Laboratory of Dairy Science of Ministry of Education, Northeast Agricultural University, Harbin 150030, China)
  • Received:2013-08-28 Online:2014-03-20 Published:2014-05-15

Abstract: To investigate the effect of essential amino acids on LAT1 expression in lactation mammary gland, the lactation mammary acini were cultured and LAT1 and 4F2hc expression were detected by Western blotting. The results showed that essential amino acids upregulated LAT1 and 4F2hc expression significantly in lactation mammary acini of dairy cow. It revealed that LAT1 was the mainly amino acid transporter in lactation mammary gland. The expression of LAT1 and 4F2hc was induced by essential amino acids.

Key words: mammary acinus; essential amino acid; LAT1; 4F2hc