分泌型IgA对肠道黏膜免疫的研究进展

Abstract

Abstract: Secretory IgA (SIgA) as a antibody which is packaged in the intestinal mucosal, could protect the gut from pathogenic microorganisms and toxins attack without causing an inflammatory reaction, plays an important role in mucosal immunity and intestinal homeostasis. In animal intestine studies, SIgA blocks pathogenic microorganisms invade the mucosa-associated lymphoid tissue, through the regulation of intestinal epithelial cell receptor recognition ability. Subsequently SIgA promotes to entrap them in mucus, and facilitate their removal by peristaltic and mucociliary activities. In addition, recently it has also been reported that SIgA reveals new mechanism in intestinal epithelial cell. We summarize the intrinsic biological activities now associated with SIgA and their relationships with immunity and intestinal homeostasis,and try to explore the potential role of SIgA transcytosis mechanism.

Key words: secretory IgA; mucosal immunity; intestinal homeostasis; transcytosis mechanism

CLC Number:

S852.4^＋2

ZHAO Xue, ZHANG Hui, LIU Yu, LI Wei, GUO Feng, FU Zhi-ling, YANG Yan-hong, WU Tian-cheng, ZHENG Xin. Research Advances on Secretory IgA Roles in Intestinal Mucosal Immunity[J]. , 2013, 40(6): 96-99.

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Research Advances on Secretory IgA Roles in Intestinal Mucosal Immunity

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