抗分泌性腹泻药物的研究进展

Abstract

Abstract: Infectious diarrhoea, particularly that due to pathogenic bacteria, is a major health problem worldwide. A variety of mechanisms have been identified by which enteropathogenic bacteria and their products can induce secretory processes in the intestine now. The major focus for many years has been the enterocyte (intracellular drug targets) and consequently this has been viewed as the most rewarding site for directing research and development into novel antisecretory agents. However, in recent years other secretory mechanisms have been discovered which include a role for endogenous secretagogues and the enteric nervous system.

Key words: diarrhoea; secretory; target site; regulate

CLC Number:

S816.79

ZHANG Jun, WANG Yue-ying, ZHA Guang-ming, LI He-ping. Advance in Antisecretory Drugs for Diarrheal[J]. , 2013, 40(2): 166-168.

References

1 Aikawa N, Karasawa A, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on intracellular cyclic nucleotide-mediated intestinal ion secretion in rats. Eur J Pharmacol,2000,394(2～3):233～236.
2 Banks M R,Casburn-Jones A C, Farthing M J. Cholera toxin (CT), Escherichia coli heat labile (LT) and heat stable toxin (STA) have an indirect effect on distal intestinal fluid transport in the rat small intestine. Gut,2002(supplⅡ):A69.
3 Banks M R, Farthing M J, Robberecht P, et al. Anti-secretory actions of a novel vasoactive intestinal polypeptide(VIP) antagonist in human and rat small intestine. Br J Pharmacol,2005,144(7):994～1001.
4 DiCesare D, DuPont H L, Mathewson J J, et al. A double-blind, randomized, placebo-controlled study of SP303(Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. Am J Gastroenterol,2002,97(10):2585～2588.
5 Farthing M J. Antisecretory drugs for diarrheal disease. Dig Dis,2006,24(1～2):47～58.
6 Ma T, Thiagarajah J R, Yang H, et al. Thiazolidinone CFTR inhibitor identified by high throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest,2002,110(1):1651～1658.
7 Plotnikoff N P, Kastin A J, Coy D H,et al.Neuropharmacological actions of enkephalin after systemic administration. Life Sci, 1976,19(8):1283～1288.
8 Powell D W, Field M. Pharmacological approaches to treatment of secretory diarrhea.In Field M, Fordtran J S, Schultz S G (eds).Secretory Diarrhea. Bethesda:American Physiological Society,1980.
9 Theodorou V, Chovet M, Eutamene H, et al. Antidiarrhoeal properties of a novel sigma ligand (JO 2871) on toxigenic diarrhoea in mice: Mechanisms of action. Gut,2002,51(4):522～528.
10 Turvill J L, Connor P, Farthing M J. Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Gastroenterology,2000,119(4):1037～1044.

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Advance in Antisecretory Drugs for Diarrheal

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