A型塞尼卡病毒检测方法及疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2022.06.034

Abstract

Abstract: Senecavirus A (SVA), also known as Seneca Valley virus (SVV), is a member of the genus Senecavirus in the family Picornaviridae.SVA mainly causes vesicular disease in pigs, which is similar to clinical symptoms such as foot-and-mouth disease, vesicular stomatitis and porcine vesicular disease, it can lead to acute death of newborn piglets and seriously affect the development of pig industry.Since the occurrence of SVA infection in Guangdong province in 2015, the disease has been reported in many provinces in China.At present, due to the lack of immune barrier against SVA in pigs in China and the strong infectivity of the disease, there is a potential risk of large-scale outbreak.How to effectively prevent and control SVA infection is an urgent problem to be solved.A variety of SVA diagnostic methods have been developed for early differential diagnosis under laboratory and field conditions.The isolation and identification of SVA, in situ hybridization and immunohistochemistry can be used to detect the existence of pathogens and their relationship with morphological changes in tissues.Serological diagnostic methods include indirect ELISA based on different structural proteins, competitive ELISA, homogeneous photoluminescence immunoassay and virus neutralization test.The detection of antibodies by immunological methods is helpful to understand the process of SVA infection and is the main means of clinical diagnosis.Virus nucleic acid detection methods mainly include PCR technology, isothermal amplification technology, genome sequencing and other molecular biological technologies, which play an important role in the early rapid detection of virus infection and the detection of new viruses.At present, there is still no commercial vaccine to prevent SVA infection, but researchers have developed a variety of potential candidate vaccines such as inactivated vaccine, attenuated vaccine, nucleic acid vaccine and subunit vaccine.The author systematically summarized the latest progress of SVA detection methods and vaccine research and development, in order to provide reference basis for the prevention and control of SVA infection.

Key words: Senecavirus A (SVA); swine; detection method; vaccine

CLC Number:

S852.65⁺1

WANG Qianqian, YU Yongle, LI Yuehua, DONG Yaqin, NI Bo, LIU Fuxiao. Advance in Detection Methods and Vaccines of Senecavirus A[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(6): 2336-2346.

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Advance in Detection Methods and Vaccines of Senecavirus A

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