动物细胞低氧培养相关调控因子研究进展

doi:10.16431/j.cnki.1671-7236.2022.05.033

Abstract

Abstract: In recent years,hypoxic cell culture has gradually become a research hotspot.It has been reported that hypoxic conditions can improve cell expansion in vitro growth kinetics,cell proliferation rate and stem cell differentiation and other functions.Hypoxia inducible factor-1α (HIF-1α) is a key factor in response to hypoxia stress and also a transduction center mediating hypoxia signal.Vascular endothelia growth factor (VEGF),hypoxia-induced mitogenic factor (HIMF) and erythropoietin (EPO) and so on are important target genes and their interactions play an important role in cell development under hypoxia conditions.In this paper,the research status of hypoxic cultured cells and the regulation mechanism and role of hypoxia-related factors were summarized,so as to provide theoretical data for exploring the mechanism of cell hypoxia,and provide more research ideas for the adaptation to altitude hypoxia and the treatment of altitude diseases.

Key words: hypoxic culture cells; hypoxy-related factors; regulatory mechanism

CLC Number:

S852.33

ZHANG Lan, YAO Yifan, CHEN Shuwu, MA Fangfang, XU Jin, YANG Kun. Research Progress on Regulatory Factors Related to Hypoxic Culture of Animal Cells[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1926-1933.

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Research Progress on Regulatory Factors Related to Hypoxic Culture of Animal Cells

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