新型莫西菌素浇泼剂对羊蜱蝇和消化道线虫驱虫药效评价

doi:10.16431/j.cnki.1671-7236.2021.05.030

Abstract

Abstract: The purpose of this study was to evaluate the clinical efficacy of a novel pour-on agent of moxidectin (MOX) on Melophagus ovinus and gastrointestinal tract nematodes in sheep through the expelling test of MOX on sheep.150 Altay ewes were randomly divided into 6 groups,25 in each group,control group without medication,diazinon medical bath group,MOX injection group and MOX pour-on agent low (0.05 mL/(kg·BW)),medium (0.1 mL/(kg·BW)) and high (0.2 mL/(kg·BW)) groups.The experiment lasted for one week.On the first day of the experiment,the method and dosage of the above-mentioned grouping were used to expel insects once.The clinical manifestations,body temperature,pulse rate,respiration (TPR),blood physiological,biochemical and urine routine indexes were observed.The reduction rate and cure rate of Melophagus ovinus were determined.Fecal samples were taken to determine the reduction rate and negative conversion rate of egg number per gram (EPG) of feces.The results showed that compared with the control group without medication,there were no significant differences in TPR,blood physiological,biochemical and urine routine indexes among the groups on the 7th day after administration (P>0.05).The reduction rate of Melophagus ovinus was 43.7% in diazinon medical bath group,and 100% in MOX injection group and MOX low,medium and high dose groups.The cure rate of diazinon medical bath group was 13.0%,while that of MOX injection group and MOX low,medium and high dose groups were all 100%.Compared with the control group without medication,the reduction rate of gastrointestinal tract nematode eggs of diazinon medical bath group was 0,while that of MOX injection group and MOX low,medium and high dose groups were 91.6%,93.1%,94.9% and 97.8%,respectively.The negative conversion rate of diazinon medical bath group was 0,while that of MOX injection group and MOX low,medium,and high dose groups were 77.0%,69.2%,69.2% and 84.6%,respectively.The results showed that the novel pour-on agent of MOX had a significant effect on ectoparasites and gastrointestinal tract nematodes,which was better than the diazinon medical bath and equivalent to MOX injection.In practice,the optimal dose of MOX was 0.5 mL/(10 kg·BW)(0.25 mg/(kg·BW)).

Key words: sheep; parasites; pour-on agent of moxidectin; pharmacodynamics

CLC Number:

S859.79^＋5

LI Xin, CHEN Zhuo, ZHONG Chi, REN Qianglin, JIN Xiaoye, YE Qianwen, XIA Ruiyang, LI Ziqian, MA Yicheng, SHU Zhan, HAO Zhihui, XU Yumei, YAO Gang. Evaluation on the Pharmacodynamics of a Pour-on Agent of Moxidectin Against Melophagus ovinus and the Gastrointestinal Tract Nematodes in Sheep[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(5): 1784-1793.

References

[1] BUXTON P A.Discussion on prevention and treatment of parasitic diseases:Some recent work on the louse[J].Proceedings of the Royal Society of Medicine,2016,34(4):178-181.
[2] KENYON F,MCBEAN D,GREER A W,et al.A comparative study of the effects of four treatment regimes on ivermectin efficacy,body weight and pasture contamination in lambs naturally infected with gastrointestinal nematodes in Scotland[J].Interna-tional Journal for Parasitology Drugs and Drug Resistance,2013,3(1):99-103.
[3] 中华人民共和国国家质量监督检验检疫总局中国国家标准化管理委员会.GB/T 19526-2004.羊寄生虫病防治技术规范[S].北京:中国标准出版社,2005. STANDARDIZATION ADMINISTRATION OF CHINA,GENERAL ADMINISTRATION OF QUALITY SUPERVISION,INSPECTION AND QUARANTINE OF THE PEOPLE'S REPUBLIC OF CHINA.GB/T 19526-2004.Technical specifi-cation for the prevention and treatment of sheep parasitic diseases[S].Beijing:China Standard Press,2005.(in Chinese)
[4] 解晓钰,王光雷.放牧羊只的最佳驱虫时间[J].新疆畜牧业,2008,2:34-35. XIE X Y,WANG G L.The best deworming time for grazing sheep[J].Xinjiang Xumuye,2008,2:34-35.(in Chinese)
[5] 王海兄.放牧牛羊寄生虫病防治工作调查及存在的问题[J].青海畜牧兽医杂志,2015,45(4):32-33. WAMG H X.Investigation on the prevention and treatment of parasitic diseases in cattle and sheep grazing and existing problems[J].Chinese Qinghai Journal of Animal and Veterinary Sciences,2015,45(4):32-33.(in Chinese)
[6] PETER B.Diazinon for control of sheep scab[J].The Veterinary Record,2020,186(8):254-255.
[7] 张波.羊给药四法的技术要点[J].畜牧兽医科技信息,2015,11:60-61. ZHANG B.Technical points of four methods of sheep administration[J].Chinese Journal of Animal Husbandry and Veterinary Medicine,2015,11:60-61.(in Chinese)
[8] 刘营营,岳治光,吴宁鹏,等.伊维菌素长效透皮剂和普通注射剂在家兔体内的药代动力学比较研究[J].中国畜牧兽医,2020,47(1):267-274. LIU Y Y,YUE Z G,WU N P,et al.Comparative study on pharmacokinetics of long acting transdermal agents of ivermectin and common injection in rabbits[J].China Animal Husbandry & Veterinary Medicine,2020,47(1):267-274.(in Chinese)
[9] 岳城.由英国家畜驱虫药抗药性的研究现状看在我国开展此项工作的重要性[J].中国兽医寄生虫病,2004,4:59-60. YUE C.The research status of deworming drug resistance in British livestock shows the importance of this work in China[J].Chinese Journal of Animal Infectious Diseases,2004,4:59-60.(in Chinese)
[10] PAPICH M G.Saunders Handbook of Veterinary Drugs:Small and Large Animal[M].Elsevier Veterinary Inc,2016.
[11] RIZK M A,OSMAN S A,GAABARY M H,et al.Comparative clinical and parasitological efficacy of moxidectin pour-on,ivermectin,and piperazine citrate on Toxocara vitulorum infection in buffalo calves (Bubalus bubalis):A randomized clinical trial[J].Turkish Journal of Veterinary and Animal Sciences,2018,42(1):145-148.
[12] HAR N.Responsible use of moxidectin in sheep[J].Veterinary Record,2020,186(5):161-164.
[13] MILLS P,CROSS S.Transdermal drug delivery:Basic principles for the veterinarian[J].Veterinary Journal,2006,172(2):218-220.
[14] NIXON S A,WELZC,WOODS D J,et al.Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics[J].International Journal for Parasitology:Drugs and Drug Resistance,2020,14(8):98-100.
[15] 李娇,李庆山,徐凤波.莫西菌素在畜牧业中的应用研究进展[J].中国畜牧兽医,2018,45(12):3587-3593. LI J,LI Q S,XU F B.Research progress of moxidectin in animal husbandry[J].China Animal Husbandry & Veterinary Medicine,2018,45(12):3587-3593.(in Chinese)
[16] 孔繁瑶.家畜寄生虫学[M].第2版.北京:中国农业大学出版社,2010. KONG F Y.Parasitology of Domestic Animals[M].2nd Edition.Beijing:China Agricultural University Press,2010.(in Chinese)
[17] FERNANDEZ D.Fecal egg counting for sheep and goat producers[J].Animal Science,2012,1:213-221.
[18] 中华人民共和国农业农村部.中华人民共和国农业部公告第1596号公告兽用中药、天然药物临床试验技术指导原则[Z].2011. MINISTRY OF AGRICULTURE AND RURAL AFFAIRS OF THE PEOPLE'S REPUBLIC OF CHINA.Announcement of the Ministry of Agriculture of the People's Republic of China No.1596.Technical guidelines for clinical trials of veterinary traditional Chinese medicine and natural medicine[Z].2011.(in Chinese)
[19] HENDRIX C M,SIROIS M著.夏兆飞译.兽医临床实验室手册[M].第5版.北京:中国农业大学出版社,2010. HENDRIX C M,SIROIS M (author).XIA Z F (translator).Laboratory Procedures for Veterinary Technicians[M].5th Edition.Beijing:China Agricultural University Press,2010.(in Chinese)
[20] KAUFMAN P E,SCHOLL P J,RUTZ D A.Dose confirmation study of a 10 g liter^-1 non-aqueous injectable formulation of moxidectin against naturally acquired infestations of cattle lice on cattle in New York[J].Pest Management Science,2015,55(9):919-922.
[21] 陈杖榴.兽医药理学[M].北京:中国农业出版社,2007. CHEN Z L.Veterinary Pharmacology[M].Beijing:China Agriculture Press,2007.(in Chinese)
[22] HIALGOA M,NATIVIDAD D,ROJOV F.Efficacy of moxidectin 1% injectable and 0.2% oral drench against natural infection by Dictyocanlusfilaria in sheep[J].Veterinary Parasitology,2002,107(1):95-97.
[23] VADLEJCH J,MAKOVICH Y P,CADKOVA Z,et al.Efficacy and persistent activity of moxidectin against natural Muellerius capillaris infection in goats and pathological consequences of muellerio-sis[J].Veterinary Parasitology,2016,218:98-101.
[24] GIBALDI M,BOYES R,FELDMAN S.Influence of first pass effect on availability of drugs on oral administration[J].Journal of Pharmaceutical Sciences,2010,60(9):1338-1340.
[25] CHIOU W.Equations for estimation of first-pass effect and apparent distribution volume of drug with incomplete oral absorption and partial renal excre-tion[J].Journal of Pharmaceutical Sciences,2010,68(2):260-262.

Evaluation on the Pharmacodynamics of a Pour-on Agent of Moxidectin Against Melophagus ovinus and the Gastrointestinal Tract Nematodes in Sheep

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