›› 2011, Vol. 38 ›› Issue (1): 92-94.

• 生物技术 • Previous Articles     Next Articles

Advance on RNA Interference and the Regulation of its Silencing Pathways

DENG Qing-hua1,LIU Guo-wen1,FU Shi-xin1,2,LIU Lei1,WANG Xiao-xu1,ZHU Xiao-yan1,
WANG Jian-guo1,BAI Ge1, WANG Zhen-quan1,LI Xiao-bing1, WANG Zhe1

  1. (1.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China;2.College of Animal Science & Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing 163319,China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-01-01 Published:2011-01-01
  • Contact: WANG Zhe;LI Xiao-bing

Abstract: RNA interference (RNAi) is induced by double-stranded RNA and result in specific degradation of double-stranded mRNA in cell,and it belongs to post-transcriptional gene silencing mechanism. RNAi has been extensively used as a novel and effective tool for functional genomic studies,and has displayed great potential in treating human and animal diseases. The paper aims to summarise the process of RNAi and make statement about biogenesis of small RNAs,safeguards and regulation of silengcing pathways.

Key words: small RNA; small interference RNA; RISC; Argonaute protein

CLC Number: