安普霉素及其联合用药对3种细菌体内抗生素后效应的研究

Abstract

Abstract: The post antibiotic effect (PAE) of apramycin and combined with amoxicillin or ampicillin against Staphylococcus aureus, Salmonella, Escherichia coli in vivo, were studied by the method of colony counting and neutropenia associated with mouse thigh with bacterial infection model. The experimental results showed that, the PAE of apramycin were conspicuous against Staphylococcus aureus, Salmonella, Escherichia coli in vivo, and were enhanced with the increasing concentration, showing strongly a concentration-dependent. Apramycin combined with amoxicillin or ampicillin had synergetic effect on the PAE of Staphylococcus aureus, Salmonella, Escherichia coli in vivo.

Key words: apramycin; post antibiotic effect; Staphylococcus aureus; Salmonella; Escherichia coli

CLC Number:

S859.79+6

ANG Xin;CUI Yi-zhe;HUANG Bao-ming;NI Hong-bo;XIA Cheng;SHAO Hong;HAN Tie-suo. Studied on the PAE of Apramycin and Combined with Amoxicillin or Ampicillin against three Bacteria in vivo[J]. , 2010, 37(7): 186-188.

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Studied on the PAE of Apramycin and Combined with Amoxicillin or Ampicillin against three Bacteria in vivo

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