Abstract: To explore the protective effects and the possible defense mechanisms of Shenmai injection on acute lung injury(ALI), and provide a new therapeutic method and the data on clinic treatment to ALI. Wister rats were randomly divided into three groups of the control group, the oleic acid group and the Shenmai injection group, and each group was used the method of intravenous injection of oleic acid classic ALI modle. The expression of ICAM-1 and TNF-α in lung homogenate were examined meanwhile examining lung coeffcients, pathological section, ultrastructure each group of rats in lung tissue, and the histopathologieal change of lung tissue were observed. The results showed that the lung coeffcients markedly changes in ALI, the pathological of morphology and ultrastructure of lung tissue significantly reduce compared with the oleic acid group, and meanwhile the ICAM-1 and TNF-α expression of the Shenmai injection group increasingly increased compared with control group. Confirmed that Shenmai injection can lighten oleic acid induced ALI, and cut down the expression of TNF-α and ICAM-1 in lung tissue. So it has a certain function to the early the ALI.

Key words: acute lung injury (ALI); Shenmai injection; protective effects