Abstract: 【Objective】 This experiment was aimed to evaluate the safety of Banqing granules on pigs, and provide reference for clinical rational drug use. 【Method】 32 healthy pigs of about 110 days of age were selected and randomly divided into recommended dose (100 mg/kg BW), triple dose (300 mg/kg BW), fivefold dose (500 mg/kg BW) groups of Banqing granules, and control group, with 8 pigs in each group.Pigs in experimental groups were administered in drinking water for 14 days and continued observation for 10 days after withdrawal.Pigs in control group were raised normally without medication.Clinical manifestations of experimental pigs were observed and recorded one by one in the morning and afternoon every day.The pigs were weighed before administration (experiment day 0, D0), after administration (experiment day 15, D15) and after observation (experiment day 25, D25), and blood was collected after fasting weighing to detect blood routine and blood biochemical indexes.Histopathological examinations were performed on animals in fivefold dose group and control group after administration and after observation, respectively. 【Result】 During the experiment, the mental state, appetite and bowel movements of pigs in each dose group were normal, and the growth performance indexes were not significantly different (P＞0.05).Blood routine index results showed that the number of red blood cells and hemoglobin content of pigs increased with the increase of dose, but both fluctuated within the normal range, and the other individual indicators had significant differences but no dose correlation and the index values were within the normal range.Blood biochemical index results showed that serum total protein of pigs increased with the increase of administration concentration, blood glucose content of pigs decreased with the increase of administration concentration but all fluctuated within the normal range, and other individual indexes showed significant differences but no dose correlation and the index values were all within the reference range of historical data.The histopathological results showed that the heart, liver, spleen, lung and kidney of pigs in fivefold dose group had clear structure, distinct layers and normal development, and no pathological changes related to the action of Chinese medicine were found, such as cell degeneration, necrosis and inflammatory cell infiltration, and no significant differences were found between the tissues and control group. 【Conclusion】 Fivefold dose of Banqing granules (500 mg/kg BW) was safe for pigs.

Key words: Banqing granules; pig; blood routine index; blood biochemical index; safety