›› 2017, Vol. 44 ›› Issue (11): 3149-3155.doi: 10.16431/j.cnki.1671-7236.2017.11.007

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Hypoglycemic Effect of Soluble Epoxide Hydrolase Inhibitors on Diabetic Mice

GAO Wan-ting1, MING Liang1, HE Jing1, BAI Na1, GUO Yan1, YI Ri-gui1, Jirimutu1,2   

  1. 1. Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China;
    2. Camel Protection Association of Inner Mongolia, Badajilin 737300, China
  • Received:2017-06-26 Online:2017-11-20 Published:2017-11-21

Abstract:

In order to study the hypoglycemic effect of soluble epoxide hydrolase inhibitors (sEHI) on diabetic mice,the diabetic mice model were successfully induced by high-fat diet and streptozotocin (STZ). The diabetic mice (C57BL/6J) were randomly divided into three groups,including normal control group,diabetic control group and sEHI group,the mice in three groups were fed high-fat diet+1 mg/kg sEHI (t-AUCB),high-fat diet+same volume normal saline,normal diet+same volume normal saline,respectively,and intervention last for 4 weeks. During the experiment,the body weight,blood glucose were recorded,and performed oral glucose tolerance test was conducted. After the experiment,indicators of serum lipids,liver peroxidation and pathological analysis of pancreatic tissue were measured. The results showed that compared with diabetic control group,the fasting blood glucose of mice in sEHI group was significantly reduced (P<0.05),and their glucose tolerance was improved. And the TC (P<0.05),TG (P<0.05) and LDL (P>0.05) in sEHI group were decreased,while the LDL/TC was significantly increased (P<0.05).The SOD and CAT activity in liver of diabetic mice treated with sEHI were significantly increased (P<0.05) and MDA activity was significantly decreased (P<0.05).Based on mouse pancreatic tissue sections,we speculated that sEHI had ability to repair activity on damaged islet tissue. In conclusion,the sEHI could reduce the blood glucose level and the free radical damage,inhibit lipid peroxidation,repair of damaged islet tissue in mice.

Key words: type Ⅱ diabetes; soluble epoxide hydrolase inhibitors (sEHI); antidiabetics; serum lipid parameter

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