口服紫锥菊对清醒比格犬心率、心电、血压和呼吸的影响

China Animal Husbandry & Veterinary Medicine

Previous Articles Next Articles

Effects of Oral Echinacea purpurea on Heart Rate，ECG, Blood Pressure and Respiration of Awake Beagle Dogs

PANG Yun-lu¹，ZHONG Ying-jie¹，FU Hai-ning¹，ZHONG Yan²，JIANG Yi-hai¹

1.Qingdao Vland Biotech Co.,Ltd.,Qingdao 266111,China；2.Shanghai Institute of Pharmaceutical Industry,Shanghai 200040,China

Received:2014-01-09 Online:2014-08-20 Published:2014-08-22

Abstract

Abstract: The experiment studied the effects of oral Echinacea purpurea on heart rate， ECG, blood pressure and respiration of awake Beagle dogs. Experimental results showed that oral Echinacea purpurea 0.125 to 1.25 g/kg could apparently reduced the heart rate of awake Beagle dogs, and had no significant effects on blood pressure, respiration and ECG between P wave, T wave, R wave, QT interval, PR interval as well as QRS duration （P>0.05）. It showed that Echinacea purpurea had no apparent effects on the dog’s respiratory system and cardiovascular system, which was safe and reliable in application doses.

Key words: Echinacea purpurea; general pharmacology; respiratory system; cardiovascular system

PANG Yun-lu，ZHONG Ying-jie，FU Hai-ning，ZHONG Yan，JIANG Yi-hai. Effects of Oral Echinacea purpurea on Heart Rate，ECG, Blood Pressure and Respiration of Awake Beagle Dogs[J]. China Animal Husbandry & Veterinary Medicine.

References

1 王呜，袁昌齐，冯煦.欧美药用植物［J］.中国野生植物资源，2003，22(3): 56～57.
2 付石军, 郭时金, 张志美, 等. 紫锥菊的药理作用及其在动物生产中的应用［J］. 中国饲料, 2013(7): 28～31.
3 肖正中, 邬苏晓. 紫锥菊提取物对小鼠免疫功能的影响［J］. 江苏农业科学, 2011, 3: 112.
4 张立永，利凯，李亚男，等. 不同剂量替米考星对塞北兔血压及心率的影响［J］.中国畜牧兽医， 2010， 37(7): 184～185.
5 张白嘉, 何光星, 曹毓, 等. 双黄痛风胶囊对麻醉 Beagle犬血压、呼吸系统及心电图的影响［A］. 现代化中药制剂发展与中药药理学研究交流会论文集［C］.2009.
6 张伟, 石达友, 吕伟杰, 等. 紫锥菊根末的安全药理学研究［J］. 中国兽药杂志, 2013, 47(9): 34～36.
7 张春芳, 邴飞虹. 苜蓿皂苷降血脂胶囊对 Beagle 犬心血管及呼吸系统的影响［J］. 湖北中医学院学报, 2007， 9(4): 24～25.
8 李沛波, 田珩, 王永刚, 等. 化州柚提取物对 Beagle 犬心血管系统和呼吸系统的影响［J］. 南方医科大学学报, 2006， 26(12): 1767～1768.
9 赵丹, 孙瑶, 汤仁想, 等. 紫锥菊粉对大鼠亚慢性毒性试验［J］. 中兽医医药杂志， 2010(4): 51～54.
10 赵丹.紫锥菊粉的安全性评价研究［D］.扬州：扬州大学，2011.
11 徐培渝，庞定国，王显菊，等.紫锥菊提取物浸膏大鼠致畸试验［A］.中国西部第八届实验动物管理与学术研讨会暨四川省第二届实验动物学术年会［C］.2009.
12 Barrett B，Brown R，Rakel D，et al.Echinacea for treating the common cold：A randomized trial［J］.Ann Intern Med，2010，153: 769.
13 Foster S. Analysis of alkamides and caffeic acid derivatives from Echinacea simulata and E.paradoxa roots［J］. Planta Med, 1991,57(5): 447～449.
14 Hall H，Fahlman M M，Engels H J.Echinacea purpurea and mucosal immunity［J］.Int J Sports Med，2007，28(9)：792～797.
15 Liu Y B.Chemical and immune functions and clinic of preparations of Echinacea purpurea［J］. World Phytaned，2001，16(2): 47.
16 Parnham M J.Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation［J］.Phytomedicine，1996，3： 95～102.

Effects of Oral Echinacea purpurea on Heart Rate，ECG, Blood Pressure and Respiration of Awake Beagle Dogs

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 0

Recommended Articles

Metrics

Comments