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Effects of Oral Echinacea purpurea on Heart Rate,ECG, Blood Pressure and Respiration of Awake Beagle Dogs

PANG Yun-lu1,ZHONG Ying-jie1,FU Hai-ning1,ZHONG Yan2,JIANG Yi-hai1   

  1. 1.Qingdao Vland Biotech Co.,Ltd.,Qingdao 266111,China;2.Shanghai Institute of Pharmaceutical Industry,Shanghai 200040,China
  • Received:2014-01-09 Online:2014-08-20 Published:2014-08-22

Abstract: The experiment studied the effects of oral Echinacea purpurea on heart rate, ECG, blood pressure and respiration of awake Beagle dogs. Experimental results showed that oral Echinacea purpurea 0.125 to 1.25 g/kg could apparently reduced the heart rate of awake Beagle dogs, and had no significant effects on blood pressure, respiration and ECG between P wave, T wave, R wave, QT interval, PR interval as well as QRS duration (P>0.05). It showed that Echinacea purpurea had no apparent effects on the dog’s respiratory system and cardiovascular system, which was safe and reliable in application doses.

Key words: Echinacea purpurea; general pharmacology; respiratory system; cardiovascular system