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Research Progress on Toll Like Receptors Mediated Signaling Transduction Pathway

MA Si-hui1,YANG Huan2,WU Tian-cheng2,CUI Huan-zhong2,ZHANG Hui2,LI Yu-meng2,HONG Pan2,ZHENG Xin2   

  1. 1.College of Life Science,Jilin Agricultural University,Changchun 130118,China;2.College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China
  • Received:2014-02-27 Online:2014-08-20 Published:2014-08-22

Abstract: Toll like receptors (TLRs) can recognize pathogen-associated molecular patterns and raise the adaptor protein molecules containing toll IL-1 receptor (TIR) domain.Moreover,TLRs can initiate specific immune response through activating signal transduction by the MyD88-dependent pathway or TRIF-dependent pathways.This article summarizes the latest research review on structure features,distribution,ligand recognition,adaptor protein molecules participating in signal transduction and signal transduction pathway of TLRs.

Key words: toll like receptors; TIR domain; signal transduction pathway