Abstract: This experiment was conducted to study the effects of different doses of selenium protein powder on hematological variables and blood biochemistry indices of rats.Eighty healthy SD rats，average body weight was 70 g，were randomly assigned into four groups，each group had two replications，every replication had 10 rats （male and female in half）.Rats in control group were fed with basal diet，low-dose group，middle-dose group and high-dose group were fed with the diet which had 3.5，7 and 10.5 mg/kg selenium protein powder （calculated as the contains of selenium） on it，respectively.The experiment lasted for 30 days.The results showed that the hematological variables of low-dose group，middle-dose group and high-dose group were not significantly different compared with the control group （P＞0.05），and there were no significant differences in the serum GLU and TP levels among all groups （P＞0.05），the serum TG，LDL levels in the low-dose group were significantly lower than that in the control group （P＜0.05），the serum A/G，TG，CHO and LDL levels in the middle-dose group were significantly lower than that in the control group （P＜0.05），the serum ALT，AST levels in the middle-dose group were significantly higher than that in the control group （P＜0.05），the serum ALB，A/G，TG and LDL levels in the high-dose group were significantly lower than that in the control group （P<0.05），while the serum GLB, ALT, AST， BUN， creatinine and HDL levels in the high-dose group were significantly increased （P＜0.05）.The results indicated that different doses of selenium protein powder had no significant effect on hematological variables in rats，and low-dose selenium protein powder had no significant effect on blood biochemistry indices except for the indices of lipid metabolism，middle-doses and high-doses selenium protein powder had some influence on blood biochemistry indices in rats.

Key words:

selenium; rat; hematological variables; blood biochemistry indices