抗菌肽的活性机制及其分子设计研究进展

Abstract

Abstract: The antimicrobial peptides (AMPs) are a class of defense peptides that widely exist in nature, which are important components of the innate immune system. Compared to antibiotics, AMPs have some good quality, such as small molecular weight, good water-solubility, thermal stability and unique antibiotic mechanism. They can also restrain virus, fungus and even tumour. With the appearance of multidrug-resistant (MDR) bacteria and the increasing of new AMPs, the study focuses on it’s mechanism of biological activity. This paper summarizes the biological activity mechanism and molecular modification of AMPs, so as to provide theory basis for the molecular modification and the application of AMPs.

Key words: antimicrobial peptides; mechanism of activity; molecular design

ZHANG Qing-hua, WANG Qing, SHANG Tian-tian, ZHAO Zhi-yu, XU Yan-zhao, HU Jian-he. Advances on the Studies of Antimicrobial Peptide’s Active Mechanism and its Molecular Design[J]. .

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Advances on the Studies of Antimicrobial Peptide’s Active Mechanism and its Molecular Design

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