Abstract: Lactoproteins are main components of the milk which include almost all of the essential amino acids and has very high nutritive value. The synthesis of lactoproteins are regulated by amino acid transporters，Janus tyrosine kinase 2 signal transducer and activator of transcription 5 （Jak2-Stat5） and mammalian target of rapamycin （mTOR） pathway. Amino acid transporters provide materials for the synthesis of milk protein. The Stat family are signal transducer factors to regulate the expression of lactoprotein, especially Stat5. The mTOR pathway can integrate hormone such as prolactin and insulin cytokine such as EIF4E and AKT, to regulate the synthesis of milk protein. It can be deduced the study of mechanism of milk protein synthesis is very important to improve the nutritive value of milk.

Key words:

amino acid; Stat family; mTOR; insulin; lactoprotein