绵羊痘病毒E3L蛋白N端结构和功能预测

›› 2013, Vol. 40 ›› Issue (6): 85-89.

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Function Prediction and Structure Analysis of N-terminal of E3L Protein in Sheeppoxvirus

LU Chang¹, WU Guo-hua¹, YAN Xin-min¹, ZHAO Zhi-xun¹, YU Shao-xiong¹, YE Yi-you², ZHU Hai-xia¹, LI Jian¹, ZHANG Qiang¹

1. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China;
2. Animal and Plant Inspection and Quarantine Technology Center, Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen 518045, China

Received:2012-11-16 Online:2013-06-20 Published:2013-06-20

Abstract

Abstract: E3L protein is a kind of nonstructural protein of poxvirus expressed in early time. It can inhibit immunity of host cells and be ralated with virus virulence and tropism. However, E3L protein in sheeppoxvirus (SPPV) is rarely understood. We have predicted N-terminal of E3L protein in SPPV by bioinformatics methods as well as using the N-terminal of E3L proteins which have been predicted. And then the structural domains, secondary structures, tertiary structures and amino acid compositions of the above proteins have also been predicted using these online programs, such as WebLab, SWISS-MODEL and ExPASY tools. The bioinformatical analysis results show that the protein and other Zα famliy proteins have the same basic structural characteristics and structural domains, implying that the N-terminal of E3L protein in SPPV might belong to Zα famliy.

Key words: sheeppoxvirus; E3L protein; Z-DNA; bioinformatics

CLC Number:

LU Chang, WU Guo-hua, YAN Xin-min, ZHAO Zhi-xun, YU Shao-xiong, YE Yi-you, ZHU Hai-xia, LI Jian, ZHANG Qiang. Function Prediction and Structure Analysis of N-terminal of E3L Protein in Sheeppoxvirus[J]. , 2013, 40(6): 85-89.

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Function Prediction and Structure Analysis of N-terminal of E3L Protein in Sheeppoxvirus

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