Abstract: The assay was aimed to compare of propofol intravenous anesthesia and enflurane inhalation anesthesia in cardiopulmonary bypass of Bama Minipigs. 10 Bama Minipigs, the average into two groups were propofol intravenous anesthesia and enflurane inhalation anesthesia, and in preoperative, operative and postoperative the anesthesia monitoring. After openning breast, whole blood were treated with heparin, then the ascending aorta, superior vena cava and inferior vena cava were intubated respectively, and connected to a cardiopulmonary bypass machine line the CPB. The vital signs, nose temperature (NT) , heart rate (HR), mean arterial pressure (MAP), pH and blood oxygen saturation(SPO₂) of each experimental pigs were observe and recorded within before introdution of anesthesia (T0), after induction of anesthesia (T1), immediately before CPB (T2), cooling to 30 ℃ (T3), blocking the aorta former immediate (T4), blocking the aorta 4 min (T5), start thawing immediate (T6), stop CPB immediate (T7), closed chest immediately after (T8) and drawing tube operation over 10 min (T9). Two groups of weight number of pigs, operation time and anesthesia time all had no significant difference (P＞0.05). Different fluorine ether group restore spontaneous breathing a short time in propofol group (P＜0.05). Compared with the basic value(T0 and T1), the NT, HR and MAP value of the experiment pigs were significantly lower (P＜0.05). But each rooms and in the group SPO₂ value and pH were not significant different (P＞0.05). Propofol intravenous anesthesia during the operation should be based on the experimental animals of the reaction conditions appropriate adjustments propofol pump into the concentration; and different fluorine ether inhaled anesthesia during the procedure of smooth, anaeesthetic effect was good, postoperative came quickly, suitable for complicated cases, and the time was long operation.

Key words: enflurane; propofol; Bama Minipigs; cardiopulmonary bypass