Abstract: The assay was aimed to observe the effects of anesthesia by sumianxin Ⅱ,sumianxin Ⅱ combined with ketamine on respiration and circulation systems of Bama Minipigs.20 healthy grown Bama Minipigs were set for two groups, each contained 10. One group was induced with intramuscular injection of 0.1 mL/kg sumianxinⅡ, another group with intramuscular injection of 0.2 mL/kg mixture sumianxinⅡ and ketamine (1:2, V/V). The respiration rate (RR) before and after induction of these chemicals were observed respectively before surgery. Furthermore, SpO₂, P_ETCO₂, heart rate (HR), mean artery pressure (MAP) and other data were monitored as well before surgery. The results were that RR, SpO₂, MAP and HR decreased significantly 1 min after treatment of sumianxin Ⅱ (P<0.05). VE was also found to extremly significantly decrease (P<0.01). However, all observed data had no significant change before and after induction by sumianxin Ⅱ together with ketamine (P>0.05). Thus,the compound anesthesia by sumianxin Ⅱ with ketamine had no clear side effect on respiration and circulation systems. This kind of compound anesthesia was safe and reliable for surgery.

Key words: Bama Minipigs; sumianxinⅡ; ketamine; compound anesthesia; respiration; circulation