多肽PrP106-126对小脑颗粒神经元凋亡相关基因表达的影响

Abstract

Abstract: The study focused on the effects of peptides PrP106-126 on cerebellar granule neuron apoptosis-related genes expression. In this study, we detected expression changes of the cerebellar granule neuronal apoptosis gene affected by the peptide PrP106-126. The results showed that the expression of bax, caspase-3 and myc genes increased significantly after stimulated. On the contrary, the bcl-2 gene expression decreased significantly which, further confirmed that bax, caspase-3 and myc genes could induce cell apoptosis and bcl-2 gene could inhibit cell apoptosis.

Key words: transmissible spongiform encephalopathies; prion protein; cerebellar granule neuronal; cell apoptosis

CLC Number:

S852.65⁺9.7

TONG Shuang, WU Xin-tao, HUANG Zhi-qiang, YU Meng, LIU Rong-chang, WANG Heng, NING Zhang-yong. Effects of Peptides PrP106-126 on Cerebellar Granule Neuron Apoptosis-related Genes Expression[J]. , 2013, (7): 34-38.

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Effects of Peptides PrP106-126 on Cerebellar Granule Neuron Apoptosis-related Genes Expression

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