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Research Progress on Hypoxia Receptor in Plateau Mammals

HU Ming-jun1,2, DENG Xiao-yu1,2, JIANG Ming-feng1,2   

  1. 1. Key Laboratory of Animal Genetics & Breeding, State Ethnic Affairs Commission and Ministry of Education, Chengdu 610041,China;
    2. College of Life Science and Technology,Southwest University for Nationalities,Chengdu 610041,China
  • Received:2012-02-09 Online:2012-09-20 Published:2012-09-18

Abstract: Many receptor genes related to hypoxia were found in plateau mammals. The main hypoxia receptor genes were hemoglobin,NADPH oxidoreductase,mitochondrial electron transport chain components, asparagine hydroxylase,HIF1 and so on. Although, a great progress at organ level and molecular level about mammals was made in recent years, the hypoxia signal pathway is not very clear. The recent progress of hypoxia receptor genes in plateau mammals was reviewed in this paper. The profiling of hypoxia receptors in plateau mammals will help us to understand how mammals adopt to the hypoxia environment in highland.

Key words: hypoxia receptors; oxygen sensors; plateau mammal 

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