›› 2012, Vol. 39 ›› Issue (3): 65-70.

• 生物技术 • Previous Articles     Next Articles

Progress of Mannose-binding Lectin-associated Serine Protease 2

WANG Xin-ju1,2, JU Zhi-hua2, WANG Chang-fa2, LI Guo-rong1   

  1. 1. College of Life Science, Shandong Normal University,Jinan 250014,China;2. Dairy Cattle Research Center,Shandong Academy of Agricultural Sciences,Jinan 250131,China
  • Received:1900-01-01 Revised:2011-11-18 Online:2012-03-20 Published:2012-03-20

Abstract: MBL-associated serine protease (MASP) and mannan-binding lectin (MBL) are key factors of the lectin pathway of complement activation and play an important role in the defense.MBL or ficolin can form complexes with sugars presented on pathogens through its carbohydrate recognition domain (CRD) and its collagen-like region (CLR) can recognize and binding to MASP. MBL can activity the zymogens of MASP which is a key enzyme and activate the complement cascade through lectin pathway.

Key words: MASP; the lectin pathway; molecular structure; function

CLC Number: