›› 2012, Vol. 39 ›› Issue (2): 137-140.

• 疾病防治 • Previous Articles     Next Articles

Progress on the Study of the Test Methods for Bovine Leukocyte Adhesion Deficiency(BLAD)

ZHOU Li1,2, JIA Guang-le1, ZHANG Ying2, HAN Xue-qing1, LIN Xiang-mei1   

  1. 1. Chinese Academy of Inspection and Quarantine,Beijing 100121,China;2. College of Animal Science and Technology,Shanxi Agricultural University,Taigu 030801,China
  • Received:2011-08-12 Revised:1900-01-01 Online:2012-02-20 Published:2012-02-20

Abstract: Bovine leukocyte adhesion deficiency (BLAD) is a newly discovered autosomal recessive genetic disease in recent years caused by A→G mutation in the CD18 gene. The disease is characterized by greatly reduced expression of the hetero dimeric β2 integrin adhesion molecules on leukocytes resulting in multiple defects in leukocyte function and significant deficits on performance traits in Holstein cattle. The main features of sick cattle is immunity reduction,susceptibility to diseases and affecting production performance. This review focus on the progress of test methods of BLAD.

Key words: bovine leukocyte adhesion deficiency; test methods; progress on the study

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