›› 2012, Vol. 39 ›› Issue (12): 162-165.

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The Establishment and Evaluation of Rats Model of the Parkinson’s Disease Cased by 6-OHDA

LI Ze-hong1, TAO Ying-nan1,2, LIU Ji-yang1, ZHANG Fan1   

  1. 1. College of Life Science, Jilin Agricultural University, Changchun 130118,China;
    2. Tobacco Company of Liuhe County, Liuhe 130060,China
  • Received:2012-06-04 Online:2012-12-20 Published:2012-12-19

Abstract: Appplicate the 6-hydroxydopanine(6-OHDA) to manufacture the rat’s model of Parkinson’s disease (PD), through the organizations of chemical method could dectect and evaluate the model comprehensivly from the changes of the behaviour and the number changes of dopaminergic neurons of nigra after the model succeed. Fetch Wistar rat by using stereotactic method, and then inject right striatum 6-OHDA into two-point. This study showed that 6-OHDA injection striatum could induce the rat model of Parkinson’s sucessfully.

Key words: Parkinson’s disease; 6-hydroxydopamine; dopaminergic neurons

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