Abstract: The effect of Lambdacyhalothrin on bone marrow cell micronucleus,sperm abnormality,accumulation toxicity in mice. It’s 50 to select by examinations mice of health adulthood,divided into stochastically for the medicine high,middle and low doses set,positive group and blank control group,each group each 10. Dosage group was respectively given 9.18,4.59,2.29 mg/kg body weight,blank control group was the same dose isotonic Lambdacyhalothrin by intragastric administration for 4 days,positive group was 80 mg/kg body weight cyclophosphamide,evaluate the effect of the Lambdacyhalothrin to bone marrow cell micronucleus on mice. In addition takes health grown-up male mouse 50,divided into stochastically for the medicine high,middle and low dose group,masculine control group and blank control group,each group of 10. Dosage group was respectively given 9.18,4.59,2.29 mg/kg body weight,positive group was 80 mg/kg body weight cyclophosphamide and blank control group was the same dose isotonic Lambdacyhalothrin by 0.9% intragastric administration for 5 days,compute the rate of abnormal sperm.Choice healthy mouse 40,random divided 20 for store toxicity to experiment set,20 for blank control group. The experimental group used the dosage to increase progressively the continual contamination law to appraise Lambdacyhalothrin to store up the toxicity,the computation accumulation coefficient, stores up the toxicity according to the accumulation coefficient evaluation criteria appraisal.The results showed that Lambdacyhalothrin was obviously store material,it will bring serious damage to the mouse growth;sperm abnormal rate of the high monitoring team of Lambdacyhalothrin and the blank control group comparison difference were extremely remarkable;micronucleus rate of the high monitoring team of Lambdacyhalothrin and the blank control group comparison difference are extremely remarkable. Therefore, Lambdacyhalothrin was obviously store material,and had a very strong teratogenic, mutagenic effect.

Key words: Lambdacyhalothrin; accumulation toxicity; sperm abnormality; micronucleus