Abstract: Abstracts: The study explored the influence of environmental stress imitating harmful environment of rearing on self-biting disease combined with 10 serum biochemical index. 90 healthy blue foxes (half male and half female) with similar body weight were randomly divided into two groups, 60 in the stress-induced group, while 30 in the control group. Six induced-stress including bed swinging, shed transferring, confined in cage, overcrowded in cage, starvation and resting stress were used on blue foxes, The results as follows: after induced for 30 days, enzyme activity in trial group were extra-significantly lower than the control group in GPT, ALP, GSH-Px, and CAT (P＜0.01), MDA content was significantly lower than the control group (P＜0.05), while SOD activity was significantly higher than the control group (P＜0.01). The activity of ALP, CK, GSH-Px, CAT and MDA, induced for 60 days, were significantly higher than the control group (P＜0.01), SOD activity was significantly lower than the control group (P＜0.01) while GPT activity was significantly lower than the control group(P＜0.05), the activity of GOT, LDH and GLU were not affected (P＞0.05). Self-biting ratio was no significantly difference between stress-induced and control blue foxes (P＞0.05). General environmental stress showed no significantly difference on self-biting disease.

Key words: blue fox; self-biting; stress-induced; serum enzyme 