Abstract: Inflammasome are an important component of innate immunity and participate in various pathophysiological processes.NOD like recepter heat protein domain associated protein 3 (NLRP3) is one of the most extensively studied inflammasome in recent years,plays an important role in the body’s response to pathogenic microorganisms and maintenance of tissue homeostasis.NLRP3 inflammasome is composed of proteins such as NLRP3,apoptosis related spotted protein (ASC),and cysteine aspartate enzyme 1 (Caspase-1),and its activation involves multi-step signal transduction,including initiation and activation signals.The activation of NLRP3 inflammasome can promote the cleavage and activation of Caspase-1,thereby mediating the maturation and release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18,as well as the process of cell apoptosis,thus playing a key role in the body’s inflammatory response.In veterinary field,research on NLRP3 inflammasome mainly focuses on its relationship with the occurrence and development of animal diseases and its potential as a therapeutic target.Research has shown that excessive activation of NLRP3 inflammasomes is associated with various animal diseases,including bacterial,viral,parasitic,and mycoplasma infections.Therefore,the regulation of NLRP3 inflammasome has become an important strategy for the treatment of related diseases and has shown potential as a diagnostic marker for diseases.Currently,research on NLRP3 inflammasome is being comprehensively conducted in veterinary clinical practice.In recent years,researchers have developed a series of inhibitors targeting NLRP3 inflammasome,such as UK5099 and MCC950.Although these inhibitors have shown significant anti-inflammatory effects in animal models,the development of NLRP3 inflammasome inhibitors is still in its infancy，and no target drugs have been successfully marketed.Therefore,the development of novel NLRP3 inflammasome inhibitors that are closer to clinical application remains a challenge.In this paper,the NLRP3 inflammasome and its research progress in veterinary field were reviewed in order to provide reference for the application of NLRP3 inflammasome as an important target in the treatment of animal inflammatory diseases.

Key words: NLRP3 inflammasome; anti-inflammatory drug; occurence and development of diseases