Abstract: Atypical porcine pestivirus (APPV) is a new Pestivirus that has emerged in recent years and has caused significant losses to the global pig industry.APPV is considered to be the causative agent of congenital A-Ⅱ tremor in piglets,which can lead to generalized muscle tremors that interfere with feeding and ultimately death by starvation.APPV was first discovered in the United States in 2015 and has been mainly concentrated on Americas,Western Europe and East Asia.It has now been detected in several provinces and cities in China.Several methods have been developed to detect APPV infection such as PCR and serological techniques.Although some progress have been made in the study of APPV,the understanding of its origin,epidemiology and transmission dynamics is still very limited.The difficulty of isolating and culturing APPV and the lack of suitable alternative experimental animal models have limited the development of commercial vaccines,making prevention and control challenging.The author reviewed recent national and international advances in APPV evolution and typing,genome structure,pathogen isolation and culture,tissue tropism and transmission routes,pathogen detection techniques and vaccine development,with a view to fully understanding its protein function and molecular mechanism,in order to provide theoretical basis for researchers to develop effective diagnostic tools and successful control strategies.

Key words: Atypical porcine pestivirus; congenital tremor; pathogen isolation; vaccine development