Abstract: 【Objective】 The purpose of this experiment was to study the application effects of small-cell fully-closed partition hoggery on pig epidemic control, purification and vaccine reduction.【Method】 All negative, all positive and partial positive groups of Porcine circovirus type 2 (PCV2) serum antibody were set up in this experiment.6 same-aged nursing pigs were selected in each group and fed as mode A and B for 140 days.Mode A was fed in small-cell fully-closed partition hoggery for 140 days, and mode B was first fed in small-cell fully-closed partition hoggery for 70 days and then fed in common opened hoggery for 70 days.All pigs were immunized with Classical swine fever virus (CSFV) and Pseudorabies virus (PRV) vaccine only once.The serum antibody levels and positive rates of PCV2, Porcine reproductive and respiratory syndrome virus (PRRSV), CSFV, PRV-gB and PRV-gE were detected on the 0, 70, 140 feeding day.【Result】 The results showed that compare with the 0 day, the PCV2 antibody level of all groups and serum antibody positive rate of all positive and partial positive groups in modle A decreased significantly (P<0.05) on the 70th and 140th day.In mode B, compare with the 0 day, the PCV2 antibody level were extremely significantly decreased in all positive group (P<0.01) and maintained in all negative and partial positive groups on the 70th day, and were extremely significantly increased in all groups on the 140th day (P<0.01).The serum antibody positive rate of PCV2 in mode B decreased greatly in the first 70 days and increased greatly to 100% in the last 70 days.Compare with the 0 day, the antibody level and serum antibody positive rate of CSFV were increased significantly (P<0.05) in mode A and B in the first 70 days.Compare with the 70 day, the antibody level of CSFV increased slightly in all negative and partial positive groups, and the serum antibody positive rate maintained 100% in all negative group and all positive group of mode A in the last 70 days.In the last 70 days, compare with the 70 day, the antibody level of CSFV decreased significantly (P<0.05) and approached the level of day 0 in all negative group and all positive group of mode B.In the first 70 days, the antibody level and serum antibody positive rate of PRV-gB decreased in some groups, and decreased in all groups in the last 70 days in mode A and B.In the whole experimental period, the antibody levels of PRRSV and PRV-gE were at a low level, and the serum antibody positive rates were 0.【Conclusion】 The small-cell fully-closed partition hoggery could significantly block the transmission of PCV2, purify PCV2, enhance the CSFV vaccine immunity protection rate, and reduce vaccine cost and was a feasible guarantee equipment to enhance the disease prevention ability of pig breeding and has broad application prospects.

Key words: small-cell fully-closed partition hoggery; epidemic disease control; epidemic disease purification