生地黄与马兜铃配伍缓解马兜铃毒性的研究

doi:10.16431/j.cnki.1671-7236.2021.06.036

Abstract

Abstract: This study was aimed to explore the effect of compatibility of Rehmannia glutinosa and Aristolochia on the liver and kidney of chickens,and provide modern theoretical basis for the compatibility and detoxification of traditional Chinese medicine.80 male chickens were randomly divided into 10 groups:Control group,Aristolochia high,medium and low dose groups,Rehmannia glutinosa high,medium and low dose groups,Aristolochia with Rehmannia glutinosa high,medium and low dose groups.After decocting,filtering and centrifuging,the impurities were removed and the decoction was made.The drug was given by gavage every day for 28 days.The liver and kidney indexes of AST,ALT,Cr and BUN, and T-AOC,SOD,GSH-Px and MDA were detected by kit.The liver and kidney were collected and sectioned to observe the histopathological changes.The results showed that compared with Aristolochia group,the contents of AST,ALT,Cr and BUN were significantly decreased (P<0.05),and the contents of T-AOC,SOD and GSH-Px were significantly increased after compatibility of Rehmannia glutinosa.The combination of Rehmannia glutinosa and Aristolochia could significantly reduce the content of MDA (P<0.05),and slow down the oxidative damage of Aristolochia.The pathological results showed that the compatibility of Rehmannia glutinosa and Aristolochia could significantly reduce the pathological damage of liver and kidney caused by Aristolochia decoction.In conclusion,the combination of Aristolochia and Rehmannia glutinosa could alleviate the liver and kidney injury in mice,and improve the drug safety of Aristolochia.

Key words: Aristolochia; Rehmannia glutinosa; compatibility of traditional Chinese medicine; toxic remission

CLC Number:

S853.7

SHI Bendong, WEI Jiayu, LIU Jinsong, SUN Mengqing, ZOU Lianhui, JIANG Xiaowen, YU Wenhui. Study on Compatibility of Rehmannia glutinosa and Aristolochia to Alleviate the Toxicity of Aristolochia[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(6): 2221-2229.

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Study on Compatibility of Rehmannia glutinosa and Aristolochia to Alleviate the Toxicity of Aristolochia

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