China Animal Husbandry and Veterinary Medicine ›› 2021, Vol. 48 ›› Issue (6): 2002-2010.doi: 10.16431/j.cnki.1671-7236.2021.06.013

• Physiology and Biochemistry • Previous Articles     Next Articles

Research Progress on the Regulation of Reproductive Endocrine by Total Flavonoids of Semen Cuscutae

ZHAO Qianhui, XUE Wenhui, GUO Yu, ZHANG Shuang, LI Yong, LI Chenyao, HUO Shuying   

  1. College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China
  • Received:2020-09-16 Online:2021-06-20 Published:2021-06-18

Abstract: In recent years,the Semen Cuscutae was often used in the treatment of reproductive endocrine diseases in clinic,and the effect is remarkable.Semen Cuscutae is a kind of convolvulaceae plant,which has the advantages of small side effects,no drug resistance,rich in a variety of nutrients,low cost and so on.It is a pure natural medicinal plant.The total flavonoids of Semen Cuscutae is the most effective component in Semen Cuscutae,which has the functions of preventing diarrhea,nourishing liver and kidney,improve sperm quality,enhance male function and pacifying fetus,etc.It is not only regulates reproductive endocrine activities of male and female animals,but also has pharmacological effects on immune,cardiovascular and cerebrovascular systems.Reproductive endocrine activities in animals are mainly regulated by the hypothalamus-pituitary-gonadal axis,including the secretion of reproductive hormones,spermatogenesis and follicular development,which play an important role in animal reproduction.Most of the animal reproductive endocrine diseases are linked to the hypothalamus-pituitary gonadal axis adjustment by the developmental state of the reproductive hormones and reproductive organs,reproductive hormones can cause hypothalamus-pituitary-gonadal axis functional disorders by direct effect and indirect effect.Given that hormonal drugs are currently prohibited in economic animals,there is an urgent need to study the effects and mechanisms of safe,effective and low-toxic chinese herbal medicines to lay the foundation for their wide application.In this paper,the main pharmacological effects of total flavonoids of Semen Cuscutae were described,and the regulatory effects of total flavonoids of Semen Cuscutae on different levels of endocrine activity of hypothalamus-pituitary-gonad axis were described in detail.The purpose of this study is to provide theoretical reference for further study on the target and mechanism of total flavonoids of Semen Cuscutae on the regulation of hypothalamus-pituitary-gonad axis.

Key words: total flavonoids of Semen Cuscutae; hypothalamic-pituitary-gonadal axis; reproductive endocrine; pharmacological action

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