泛素蛋白酶体途径及其在体外受精中的作用研究进展

doi:10.16431/j.cnki.1671-7236.2018.02.007

Abstract

Abstract:

The ubiquitin proteasome pathway (UPP) is the most important pathway for protein degradation in the organism,and UPP is also related with many diseases,it plays a very important role in the organism which mainly degrade misfolded proteins. UPP is a circular pathway, its main function begins with the activation of ubiquitin(Ub), and the process is a cascade process that regulated by the ubiquitin activating enzyme (E1,in yeast is UbE1), ubiquitin conjugating enzyme (E2,UbE2), ubiquitin ligase enzyme (E3,UbE3) and deubiquitinating enzymes(DUBs).Eventually make the protein substrate that labeled by polyubiquitination degrad into oligopeptides in UPP protein hydrolysis core 26S proteasome. The oligopeptides can be reused by organisms,and the Ub was removed by DUBs for the next UPP cycle. And the studies have shown that UPP plays an important role in ascidians and some mammalian in vitro fertilization (IVF) process, it can participate in sperm capacitation and acrosome reaction(AR), promote sperm acrosome exocytosis, degrade zona pellucida (ZP) protein in the process of sperm-oocyte binding, help sperm penetrate oocytes ZP, promote the fusion of sperm and oocytes ZP, so to promote the success of the IVF. And by adding some UPP related antibody or inhibitors in the IVF solution can inhibit polyspermy in the process of IVF, to improve the IVF rates. The authors mainly describes the main components of UPP and its auxiliary functions for IVF, and the research progress of the related antibody. This review may provide some theoretical basis for the future research of the mechanism of UPP cycle in organism, the relationships with various diseases in the organism, the mechanism in IVF process and the inhibition of polyspermy.

Key words: ubiquitin proteasome pathway (UPP); in vitro fertilization (IVF); ubiquitin; inhibitors

CLC Number:

Q591.2

WANG Yang, JIN Yi. Research Progress on Ubiquitin Proteasome Pathway and Its Function in vitro Fertilization[J]. , 2018, 45(2): 338-348.

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Research Progress on Ubiquitin Proteasome Pathway and Its Function in vitro Fertilization

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