线粒体融合、分裂及其相关疾病的研究进展

doi:10.16431/j.cnki.1671-7236.2017.06.001

Abstract

Abstract:

In recent years, more and more studies on mitochondrial fusion and fragmentation mechanisms have been conducted, mitochondria are double-membrane organelles possessed by all eukaryotic organisms. In most cells, mitochondria are highly dynamic and maintain their homeostasis by continually fusing and dividing.Mitochondrial outer membrane and endometrial fusion were regulated, respectively by Mfn1, Mfn2 and a variety of forms of OPA1;DRP1 mediated epineurial division,at present the mechanism of endometrial fission is still unclear,may be mediated by S-OPA1 and MTP18. Research shows that a variety of objective factors through the impact of the degree of integration or division,thus affecting the mitochondrial fusion and fission,increased mitochondrial fusion or decreased mitochondrial fission will result in the cell into individual large, small number of mitochondria;On the contrary,will lead to mitochondria appear individual small, large number. In the future research process, this feature can be used to detect indirectly a change in mitochondrial morphology factors. On the basis of summarizing the results of previous studies, in the present review, we focus on the mitochondrial fusion and fission, some related proteins involved in mitochondrial fusion and fission, as well as the occurrence of mitochondrial disease.

Key words: mitochondria; morphology; protein; dynamic change; disease occurrence

CLC Number:

Q244

HAN Yu-xuan, PANG Xin-ru, WU Yue-hong, ZHAO Hong-xin. Research Progress on the Mitochondrial Fusion, Fission and Their Effects on Disease[J]. , 2017, 44(6): 1571-1579.

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Research Progress on the Mitochondrial Fusion, Fission and Their Effects on Disease

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