吡喹酮注射液对水牛血吸虫病的临床治疗效果

doi:10.16431/j.cnki.1671-7236.2017.05.041

Abstract

Abstract:

To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg.

Key words: praziquantel injection; buffalo schistosomiasis; clinical therapeutic effect; negative conversion rate of miracidium

CLC Number:

S859.79

YANG Hai-feng, LI Yong-jun, LU Guang-fu, TAO Jian-ping. Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis[J]. , 2017, 44(5): 1552-1556.

References

[1] 汪世平,何鑫,周云飞.我国血吸虫病传染源快速检测技术的需求与发展[J].中国寄生虫学与寄生虫病杂志,2015,33(6):456-460.
[2] Steinmann P, Keiser J, Bos R, et al. Schistosomiasis and water resources development:Systematic review, meta-analysis, and estimates of people at risk[J]. Lancet Infect Dis, 2006, 6(7):411-425.
[3] Chen X Y, Wang L Y, Cai J M, et al. Schistosomiasis control in China:The impact of a 10-year World Bank Loan Project[J]. Bulletin of the World Health Organization, 2005, 83(1):43-48.
[4] 李浩,刘金明,宋俊霞,等. 2012年全国家畜血吸虫病疫情状况[J].中国动物传染病学报,2014,22(5):68-71.
[5] 刘宗传,任光辉.家畜传染源控制为主的血吸虫病防治策略实施效果[J].中国热带医学,2014,14(2):151-155.
[6] 金礼琴,陈晓兰,李勇军,等.HPLC法同时测定复方吡喹酮浇泼剂中有效成分的含量[J].中国畜牧兽医,2015,42(4):958-965.
[7] 杨海峰,李勇军,金礼琴,等.吡喹酮注射液的含量测定及稳定性研究[J].中国畜牧兽医,2015,42(11):3010-3015.
[8] 操继跃,刘恩勇,赵俊龙.黄牛静注、肌注和内服吡喹酮的药动学与生物利用度[J].中国兽医学报,2001,21(6):612-614.
[9] Sun Y, Bu S J. Pharmacokinetics and relative bioavailability of praziquantel in healthy water buffalo after oral and intramuscular administration[J].J Vet Pharmacol Therap, 2012, 35(6):618-622.
[10] 陈文行,陈雅云,王兴大,等.吡喹酮注射液治疗牛血吸虫病效果观察[J].中国兽医科技,2001,31(5):36-37.
[11] 赵俊龙,刘恩勇,李克斌,等.吡喹酮非水溶液注射剂的研制——日本血吸虫病治疗试验[J].中国兽医学报,2003,23(4):253-255.
[12] 郑新生,姚宝安,王艳蕊,等.高浓度吡喹酮注射剂的研制及对小鼠日本血吸虫病的治疗试验[J].华中农业大学学报,2006,25(1):68-70.
[13] 刘粉,费陈忠,薛飞群,等. 20%吡喹酮注射剂对小鼠人工感染血吸虫效果观察[J].中兽医医药杂志,2009,5:51-52.
[14] 中华人民共和国卫生部疾病控制司.血吸虫病防治手册[M].第3版.上海:上海科学技术出版社,2000.
[15] 汪承相,张建华,李勇.试管倒插法诊断家畜血吸虫病效果观察[J].湖北畜牧兽医,2016,37(5):5-6.
[16] 彭又新朱永杰.动物血吸虫的防治[J].中国畜牧业,2015,4:78-79.
[17] da-Sliva S P, Noel F. Praziquantel inhibits Schistosoma mansoni attachment in vitro[J]. Braz J Med Biol Res, 1990, 23:1005-1008.
[18] 杨振坤,汪伟,梁幼生.吡喹酮抗血吸虫的免疫机制研究进展[J].中国热带医学,2013,13(2):240-244.
[19] 肖树华.宿主因素在吡喹酮抗血吸虫过程中的作用[J].中国寄生虫学与寄生虫病杂志,2008,26(3):217-225.
[20] 张吉丽,李冰,周绪正,等.动物抗寄生虫药物作用机理研究进展[J].中国畜牧兽医,2016,43(1):242-247.
[21] 黄一心,肖树华.抗蠕虫药吡喹酮的研究与应用[M].北京:人民卫生出版社,2008.
[22] 农业部兽药评审中心.兽药研究技术指导原则汇编[M].北京:化学工业出版社,2011.
[23] 杨海峰.吡喹酮注射液的质量研究与临床应用评价[D].扬州:扬州大学,2014.

Clinical Therapeutic Effect of Praziquantel Injection on Buffalo Schistosomiasis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 1

Recommended Articles

Metrics

Comments