›› 2017, Vol. 44 ›› Issue (4): 1244-1248.doi: 10.16431/j.cnki.1671-7236.2017.04.043

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Research Progress and Countermeasures of Porcine Endogenous Retrovirus in Chinese Miniature

FENG Shu-tang1,2, MA Yu-yuan3, XIA Ying1   

  1. 1. Institute of Animal Sciences, China Academy of Agricultural Sciences, Beijing 100193, China;
    2. Grand Life Science and Technology Co., Ltd., Beijing 100007, China;
    3. Institute of Transfusion Medicine, The Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2016-08-29 Online:2017-04-20 Published:2017-05-03

Abstract:

The paper is a brief introduction of porcine endogenous retrovirus (PERV) innovative research results in the world and also expounds the passing PERV existence situation on different varieties of miniature pig, analyzes the PERV-virus gene cloning and sequence, appraises method on cell level, create the platform of infection HEK293 cells research, study on pigs A3F inhibition of PERV, and reveal the innovative research results on the specific molecular genetics in the different strain of PERV, analyzes the advantages of Wuzhishan miniature pig inbred line such as low gene copy of PERV,and there is no passing PERV-C specificity and as well as looking forward to cultivate the methods for new strain of PERV negative pigs. It will provide a scientific counter measure and new perspective to solve the spread of disease risk of miniature pig PERV and product safety for human xenotransplantation and biomedical materials of research and development.

Key words: Chinese miniature pig; porcine endogenous retrovirus; infectious clone; xenotransplantation

CLC Number: