nesfatin-1抑制摄食的作用及其机制研究进展

doi:10.16431/j.cnki.1671-7236.2015.08.020

Abstract

Abstract: The recently discovered nesfatin-1 is a new anorexigenic molecule.The precursor protein nucleobindin-2 (NUCB2) is proteolytically cleaved into three fragments, nesfatin-1, nesfatin-2 and nesfatin-3.The middle segment of nesfatin-1 (M30) is responsible for inhibiting food intake, while the physiological role of nesfatin-2 and nesfatin-3 are not currently known yet.nesfatin-1 plays roles in behaviour, mood, reproduction, sleeping, epilepsy and diabetic hyperphagia.We reviewed the discovery, designation, biochemical structure, distribution, its main biological function and the possible mechanism of inhibiting food intake effect of nesfatin-1.

Key words: nesfatin-1; NUCB2; food intake; anorexigenic

CLC Number:

R589.2

XIE Guang-mei, LIN Fang-jun. Research Progress on Effect and Mechanism of nesfatin-1 on Inhibiting Food Intake[J]. , 2015, 42(8): 2058-2065.

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Research Progress on Effect and Mechanism of nesfatin-1 on Inhibiting Food Intake

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