瘦素基因的研究进展

doi:10.16431/j.cnki.1671-7236.2018.09.023

摘要/Abstract

摘要：

瘦素（leptin，LEP）是白色脂肪分泌的一种蛋白质激素，在哺乳动物中，LEP是一种16-ku的肽类激素，在能量平衡的神经内分泌和外周调节中发挥重要作用，是反应体脂含量和调节体重、摄食的重要信号因子。在人类疾病方面，LEP基因的表达对很多疾病的发生起着重要的调控作用，尤其是LEP基因的突变可能导致肥胖、糖尿病和乳腺癌等疾病；在畜牧生产上，LEP基因的表达对牛、羊和猪的采食和生长性状影响显著。为了加深对LEP基因的认识，作者对LEP基因的结构及LEP的分布、结构和功能进行了总结，并对近几年LEP基因在疾病和畜牧生产方面的研究进展进行了综述。

关键词: LEP基因; 能量平衡; 信号因子

Abstract:

Leptin is a protein hormone secreted by white adipose tissue.In mammals,leptin is a 16-ku peptide hormone that plays an important role in the energy balance of neuroendocrine and peripheral regulation,which is an important signal factor for reacting body fat content and regulating body weight and feeding.In human diseases,the expression of leptin gene plays an important regulatory role in many diseases.In particular,the mutation of leptin gene may lead to diseases such as obesity,diabetes and breast cancer.In animal husbandry,the expression of leptin gene has an significant impact on the intake and growth traits of cattle,sheep and pigs.In order to deepen the understanding of leptin gene,the distribution,structure and function of leptin are summarized,and the research advances on disease and animal husbandry in recent years are reviewed in this paper.

Key words: LEP gene; energy balance; signal factor

中图分类号:

Q756

罗铮, 翁吉梅, 封竣琪, 徐伟, 罗卫星, 蔡惠芬, 陈说. 瘦素基因的研究进展[J]. 《中国畜牧兽医》, 2018, 45(9): 2524-2530.

LUO Zheng, WENG Jimei, FENG Junqi, XU Wei, LUO Weixing, CAI Huifen, CHEN Yue. Research Advances on Leptin Gene[J]. , 2018, 45(9): 2524-2530.

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