›› 2010, Vol. 37 ›› Issue (12): 42-44.

• 生理生化 • 上一篇    下一篇

胰高血糖素样肽-2的研究进展

张承勇,梁梓森,刘德辉,黄毓茂   

  1. (华南农业大学兽医学院,广州 510640)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-20 发布日期:2010-12-20
  • 通讯作者: 黄毓茂

Recent Advances of Glucagon-like Peptide-2

ZHANG Cheng-yong, LIANG Zi-sen, LIU De-hui, HUANG Yu-mao   

  1. (College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640,China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-12-20 Published:2010-12-20
  • Contact: HUANG Yu-mao

摘要: 胰高血糖素样肽-2(glucagon-like peptide-2,GLP-2)是胰高血糖素原基因(proglucagon)在肠上皮组织中由L内分泌细胞表达翻译后处理加工的产物之一,它作为一个促肠黏膜生长修复物质,促进绒毛的高度和隐窝深度的增长,同时GLP-2能恢复和维持小肠黏膜上皮屏障的完整性,促进小肠损伤后的修复等作用。因此,GLP-2 在动物营养上的应用前景广阔。作者从GLP-2的分泌与代谢、功能等方面综述GLP-2的最新研究进展。

关键词: GLP-2; 肠绒毛; 营养吸收

Abstract: Glucagon-like peptide-2(GLP-2),is post-translational processing of the proglucagon gene expressed in the intestinal enteroendocrine L-cell. It is as a growth promoting intestinal repair material, and increase villus height and crypt depth.While GLP-2 can restore and maintain the integrity of intestinal mucosa barrier,promote the repair of small intestine function after injury. Therefore,GLP-2 will be on the application prospect in animal nutrition.The author summary GLP-2 of the latest research from the GLP-2 secretion, metabolism, functions.

Key words: GLP-2; villi intestinales; nutrient absorption

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