可乐猪乳头数性状全基因组关联分析

doi:10.16431/j.cnki.1671-7236.2016.11.009

Abstract

Abstract:

Teats number is one of the most important reproductive traits,and closely related to the economic benefit in pig industry.In order to reveal the underlying genetics of left teats number,right teats number and total teats number traits,a genome-wide association study（GWAS）was performed.Samples of DNA were collected to genotyping for 22 Kele pigs using the Illumina Porcine SNP 60K Chip.The GWAS was performed using a mixed-effects model and linear regression approach.When a genome-wide threshold was determined using the Bonferroni method（P<2.06E-5),4 single nucleotide polymorphism（SNP）markers were potentially associated with left teats number,right teats number and total teat number.However,3 SNPs were significant associated and 18 SNPs were potentially associated in chromosomes level.304 Ensembl genes were retrieved around 1 cM of the associated SNPs.The candidate genes in Wnt and Fgf signaling pathway（BTRC,FGF5,FGF8,BMP3,RASGEF1B and HMGB3）might have effect on target traits.These results provided valuable information about the selective breeding for Kele pigs.

Key words: SNP chips; genome-wide association study; teats number

CLC Number:

XIE Jian, YU Chang-yan, XU Yao, NIU Xi, RAN Xue-qin, WANG Jia-fu. Genome-wide Association Study of Teats Number Traits in Kele Pigs[J]. , 2016, 43(11): 2866-2872.

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Genome-wide Association Study of Teats Number Traits in Kele Pigs

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