猪链球菌2型分解代谢控制蛋白A经NF-κB/MAPK通路对巨噬细胞RAW264.7影响的研究

Abstract

Abstract: In this study, we evaluated the stimulation of RAW264.7 macrophages with a purified expressed recombinant protein, catabolite control protein A (ccpA) of Streptococcus suis 2. The results showed that this protein could stimulate the secretion of NO and induce IL-6,TNF-α and IFN-γ in RAW264.7 macrophages if in a dose-dependent manner with specific pre-treatment of the cell cultures with iNOS, NF-κB, p38 and ERK 1/2 MAPK pathway inhibitors. This study might provide important proves for the development of regulatory factors on Streptococcus suis 2 infection.

Key words: Streptococcus suis type 2; catabolite control protein A (ccpA); NF-κB/MAPK; RAW264.7 macrophages

CLC Number:

S852.61⁺1

LANG Xu-long, RAN Hui-ling, WANG Xiu-ran, WANG Kai, BU Zhao-yang, ZHANG Rui, QIAN Jing, CHEN Si, WAN Jia-yu, WANG Xing-long. Research on the Effects of ccpA of Streptococcus suis Type 2 in RAW264.7 Macrophages though NF-κB/MAPK Pathway[J]. , 2013, 40(7): 21-24.

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Research on the Effects of ccpA of Streptococcus suis Type 2 in RAW264.7 Macrophages though NF-κB/MAPK Pathway

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