›› 2013, Vol. 40 ›› Issue (1): 93-98.

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Research Progress on Carbohydrate Response Element Binding Protein

TANG Hui1, PAN Zhi-xiong2, WANG Ji-wen2, YI Jun1, WANG Huai1, YI Li-sheng1, DENG You-fei1, GAN Jia1, E MU Qu-zhe1, FU Mao-zhong1   

  1. 1. Sichuan Animal Science Academy, Chengdu 610066, China;
    2. Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Ya’an 625014, China
  • Received:2012-07-06 Online:2013-01-20 Published:2013-01-14

Abstract: Glycolipid metabolism is the foundation of the energy sources of normal growth and development in human and animals,directly affects the animal lipid traits,therefore it has become the breakthrough point of cultivating high quality livestock and poultry breed. Carbohydrate response element binding protein(ChREBP) plays an important role in regulation of animal glycolipid metabolism in recent years,especially in major site of glycolipid metabolism-liver.In this review,the author summarised the structure characteristics,tissue distributions,mechanism of glucose-responsive,biological functions,gene expression regulation of ChREBP,and it might provide theoretical basis for following research.

Key words: carbohydrate response element binding protein(ChREBP); liver steatosis; insulin-resistance

CLC Number: