禽致病性大肠杆菌黏附素疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2023.12.027

Abstract

Abstract: Avian pathogenic Escherichia coli (APEC) is an important pathogen that causes local and systemic infections in birds of different ages,and is also an important reservoir or source of virulence genes for human extraintestinal pathogenic Escherichia coli(ExPEC).With the increasing number of APEC-resistant strains,there is an urgent need to develop effective ways to prevent and control APEC infection,and preventing bacterial infection at the initial stage is one of the most effective measures to combat infection.In addition to mediating bacterial binding to host tissues,adhesins are the first step in the successful establishment of an initial infection.Therefore,using adhesin as a target to prepare a vaccine to prevent APEC infection will be a very promising strategy.The authors focus on the structure and functions of various adhesins,including fimbrial adhesins,afimbrial adhesins (Afa) and atypical adhesins.It also discusses their potential as candidate vaccine adhesins for APEC,some of the adhesins mentioned include type 1 fimbriae,P fimbriae,common fimbriae,Yqi fimbriae,Stg fimbriae,curli fimbriae,temperature-sensitive hemagglutinin (Tsh),AatA,FdeC,YeeJ,flagellin,lipopolysaccharide (LPS), outer membrane protein A,etc.Once successfully developed,the adhesin-based vaccines is expected to become a powerful means of preventing and controlling APEC infection.

Key words: avian pathogenic Escherichia coli; adhesin; adhesin-based vaccines

CLC Number:

S852.61

MA Xingshu, SONG Jinxiang, SHI Hu. Current Progress on Adhesin-based Vaccines for Avian Pathogenic Escherichia coli[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(12): 5056-5066.

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Current Progress on Adhesin-based Vaccines for Avian Pathogenic Escherichia coli

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