应对细菌耐药策略研究进展

doi:10.16431/j.cnki.1671-7236.2023.11.025

Abstract

Abstract: Bacteria resistance is closely related with the development of animal husbandry industry, human public health safety and food safety.The mechanism of bacteria resistance is complex.In addition to the complex interaction among human, animal and environment, the use of antibiotics has played a very important impact on the generation and spread of bacterial resistance.Therefore, it is necessary to develop a variety of strategies to cope with bacterial resistance.The newly developed drug theory and the rise of molecular biology technology have greatly promoted the understanding of bacterial drug resistance mechanism, the discovery of new antibacterial drugs and the rational use of drugs, which provided important theoretical basis and technical means for the control of bacterial drug resistance.Presently, bacterial drug resistance has been a serious problem which can not be ignored and has arouse much concern.Due to the complexity of bacterial drug resistance mechanism and the difficulty of new drug development, it is necessary to carry out research through multiple methods, approaches and perspectives to prevent further development of bacterial resistance.Based on the current research, the author summarized a variety of strategies and methods to deal with bacterial drug resistance, focusing on the development of new antimicrobial drugs, drug combination, pharmacokinetic-pharmacodynamic modelling and multi-omics technology to elaborate their role in dealing with bacterial drug resistance, which would provide reference and guidance for slowing and controlling the development of bacterial resistance and clinical treatment of bacterial infection.

Key words: bacterial resistance; multidrug resistance; control strategies

CLC Number:

S859.7

LI Yafei, ZHANG Xiufeng, ZHANG Lingxuan, WEI Yanzhe, WAN Kai, ZENG Zhenling. Research Progress on Strategies to Control Bacterial Resistance: A Review[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(11): 4568-4576.

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Research Progress on Strategies to Control Bacterial Resistance: A Review

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