Abstract: Objective： to study the effect of admixture of cordyceps culture medium with different percentage on blood biochemical parameter in SPF Wistar rats. Methods： we collected eighteen items blood biochemical parameters of sixty SPF Wistar rats divided into three groups, and then these parameters were run statistical analysis. Results： Levels of HG, EOS of Wistar rats in experimental groups are lower significantly than control group's; Levels of CH, TGL of Wistar male rats in experimental groups are lower remarkably than control group's, while Levels of UN, BG of its are higher notably than control group's; Levels of GPT, GOT of Wistar female rats in experimental groups are higher significantly than control group's, while Levels of CH, TGL of its are lower notably than control group's; other parameters among other groups and different sexes do not exist difference remarkably. Conclusion： part blood biochemical parameters in SPF Wistar rats generate significant change by feeding admixture of cordyceps culture medium with different percentage.

Key words: admixture of cordyceps culture medium; SPF Wistar rat; blood biochemical parameter