杀菌/通透性增加蛋白研究现状及应用前景

›› 2009, Vol. 36 ›› Issue (9): 29-33.

杀菌/通透性增加蛋白研究现状及应用前景

李彦兵，桂祎，李进涛，李作生，史宪伟，张以芳

(云南农业大学动物科学技术学院，昆明 650201)

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-09-20 发布日期:2009-09-20
通讯作者: 张以芳

Research Progress and Application Prospect of Bactericidal/Permeability Increasing Protein

LI Yan-bing, GUI Yi, LI Jin-tao, LI Zuo-sheng, SHI Xian-wei, ZHANG Yi-fang

(Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201)

Received:1900-01-01 Revised:1900-01-01 Online:2009-09-20 Published:2009-09-20
Contact: ZHANG Yi-fang

摘要/Abstract

摘要： 杀菌/通透性增加蛋白(BPI)是中性粒细胞内存在的一种碱性蛋白，是一个分子质量介于50～60 ku的阳性蛋白，它主要存在于人、牛、兔等哺乳动物多形核粒细胞(PN4NL)的嗜天青颗粒中及其表面，它能与革兰氏阴性菌脂多糖(LPS)结合，具有中和内毒素和杀灭细菌的作用，在革兰氏阴性菌感染的治疗方面有良好的应用前景，人类最初注意杀菌性/通透性增加蛋白是因其具有杀菌作用，但随后发现它还具有较强的颉颃内毒素的作用。近年来国外对其研究颇多，并逐渐发现其还具有很多其他功能，如抗真菌、杀灭寄生虫等作用，其被学者称为未来的“超级抗生素”。

关键词: 杀菌/通透性增加蛋白; 内毒素; 中性粒细胞

Abstract: The bactericidal/permeability-increasing protein (BPI) is an antibiotic-and endotoxin-neutralizing protein in granulocytes and epithelial cells. It is a positive protein which molecular weight range between 50 and 60 ku. BPI is mainly found in azurophili granules and surface of PMN (PN4NL) from people, cattle, rabbits and other mammals. BPI can combine with the LPS and endotoxin of gram negative bacteria and produce effects of anti-endotoxin and kill bacterial. Therefore, it has a good future of application at prevention and cure of disease of Gram-negative bacterial. BPI initial found in the human protein because of its bactericidal effect and strong anti-endotoxin role. In recent research, it has been also found that it has many other functions, such as the effects of anti-fungal and killing parasites. Therefore it has been known as “super antibiotics” of the future.

Key words: bactericidal/permeability-increasing protein; endotoxin; neutrophil

中图分类号:

Q816

李彦兵;桂祎;李进涛;李作生;史宪伟;张以芳. 杀菌/通透性增加蛋白研究现状及应用前景[J]. , 2009, 36(9): 29-33.

LI Yan-bing;GUI Yi;LI Jin-tao;LI Zuo-sheng;SHI Xian-wei;ZHANG Yi-fang. Research Progress and Application Prospect of Bactericidal/Permeability Increasing Protein[J]. China Animal Husbandry & Veterinary Medicine, 2009, 36(9): 29-33.

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